Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IL‐22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis

18 Apr 2006

Abstract excerpt

IL-22 is an IFN-IL-10 cytokine family member, which is produced by activated Th1 and NK cells and acts primarily on epithelial cells. Here we demonstrate that IL-22, in contrast to its relative IFN-gamma, regulates the expression of only a few genes in keratinocytes. This is due to varied signal transduction. Gene expressions regulated by IL-22 should enhance antimicrobial defense [psoriasin (S100A7), calgranulin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dermatology and Skin Diseases
Share to Fibromyalgia and Chronic Fatigue Syndrome Research
Share to Psoriasis: Treatment and Pathogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16619290
DOI: 10.1002/eji.200535503

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IL‐22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasisPMID 16619290Read ↗

IL-22 Inhibits Epidermal Differentiation and Induces Proinflammatory Gene Expression and Migration of Human KeratinocytesSemantic proximity Read ↗

The psoriasis-associated IL-17A induces and cooperates with IL-36 cytokines to control keratinocyte differentiation and functionSemantic proximity Read ↗

The Inflammatory Response in Psoriasis: a Comprehensive Review.Semantic proximity Read ↗

The Th17 cytokine IL‐22 induces IL‐20 production in keratinocytes: A novel immunological cascade with potential relevance in psoriasisSemantic proximity Read ↗

The Effects of IL-20 Subfamily Cytokines on Reconstituted Human Epidermis Suggest Potential Roles in Cutaneous Innate Defense and Pathogenic Adaptive Immunity in PsoriasisSemantic proximity Read ↗

The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses.Semantic proximity Read ↗

The Pro-Inflammatory Cytokine IL-22 Up-Regulates Keratin 17 Expression in Keratinocytes via STAT3 and ERK1/2Semantic proximity Read ↗

Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodelingSemantic proximity Read ↗

The Role of Cutaneous Type I IFNs in Autoimmune and Autoinflammatory DiseasesSemantic proximity Read ↗

Psoriasiform dermatitis is driven by IL-36–mediated DC-keratinocyte crosstalkSemantic proximity Read ↗

Characterization and profiling of immunomodulatory genes in resident mesenchymal stem cells reflect the Th1-Th17/Th2 imbalance of psoriasis.Semantic proximity Read ↗

IL-22 Binding Protein (IL-22BP) in the Regulation of IL-22 BiologySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.