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Article

Genetic variation in the NBS1, MRE11, RAD50 and BLM genes and susceptibility to non-Hodgkin lymphoma.

BMC medical genetics - 16 Nov 2009

Schuetz Johanna M, MaCarthur Amy C, Leach Stephen, Lai Agnes S, Gallagher Richard P, Connors Joseph M, Gascoyne Randy D, Spinelli John J, Brooks-Wilson Angela R

Abstract excerpt

BACKGROUND: Translocations are hallmarks of non-Hodgkin lymphoma (NHL) genomes. Because lymphoid cell development processes require the creation and repair of double stranded breaks, it is not surprising that disruption of this type of DNA repair can cause cancer. The members of the MRE11-RAD50-NBS1 (MRN) complex and BLM have central roles in maintenance of DNA integrity. Severe mutations in any of these genes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19917125
DOI: 10.1186/1471-2350-10-117
PMCID: PMC2788526

Genes

RAD50
BLM
MRE11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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