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Cytogenetics and molecular genetics of lung cancer

6 Aug 2002

Abstract excerpt

The development and progression of lung cancer is a multistep process characterized by the accumulation of numerous genetic and epigenetic alterations, some of which occur early in the course of disease. In this review, we summarize cytogenetic imbalances and molecular genetic/epigenetic changes seen in human small-cell and non-small-cell lung cancer. Alterations of tumor suppressor genes and oncogenes leading to...

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PMID: 12407699
DOI: 10.1002/ajmg.10692

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