Article
Association of TLR4 Asp299Gly and Thr399Ile polymorphisms with Guillain-Barré syndrome in Northern Indian population.
Journal of neuroimmunology - 25 Jan 2010
Nyati Kishan Kumar, Prasad Kashi Nath, Verma Avantika, Singh Aloukick Kumar, Rizwan Arshi, Sinha Sushmita, Paliwal Vimal Kumar, Pradhan Sunil
Abstract excerpt
Molecular mimicry between Campylobacter jejuni lipopolysaccharide and host gangliosides induces an immune response leading to axonal damage and Guillain-Barré syndrome (GBS). TLR polymorphisms are associated with many autoimmune diseases. The role of the TLR4 gene in GBS susceptibility largely remains unknown. We investigated TLR4 polymorphism in GBS. One hundred and twenty GBS patients and 150 healthy controls...
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