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Article

Th17 pathway signatures in a large Indian cohort of Guillain Barré syndrome.

Journal of neuroimmunology - 15 Oct 2018

Debnath Monojit, Nagappa Madhu, Subbanna Manjula, Sundaravadivel Pandarisamy, Talukdar Pinku Mani, Shivakumar Venkataram, Wahatule Rahul, Dutta Debprasad, Binukumar B, Sinha Sanjib, Bindu Parayil Sankaran, Periyavan Sundar, Umamaheswara Rao G S, Taly Arun B

Abstract excerpt

The etiopathogenesis of Guillain Barré Syndrome (GBS) is inadequately understood. The role of immuno-inflammatory Th17 pathway was examined in GBS patients by genetic, gene expression and biochemical studies. Genotyping of G197A single nucleotide polymorphism within IL17 gene was carried out by PCR-RFLP method in 220 GBS patients. Quantification of gene expression of STAT3 and RORC and estimation of plasma level...

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PMID: 30196825
DOI: 10.1016/j.jneuroim.2018.08.001

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