Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint.

PloS one - 11 Nov 2009

Doi Nagafumi, Hoshi Yoko, Itokawa Masanari, Usui Chie, Yoshikawa Takeo, Tachikawa Hirokazu

Abstract excerpt

BACKGROUND: The central paradox of schizophrenia genetics is that susceptibility genes are preserved in the human gene-pool against a strong negative selection pressure. Substantial evidence of epidemiology suggests that nuclear susceptibility genes, if present, should be sustained by mutation-selection balance without heterozygote advantage. Therefore, putative nuclear susceptibility genes for schizophrenia...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 6
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Finland

Share to Genetics, Population

Share to Heterozygote

Share to Schizophrenia

Source

Open in PubMed Open full text

Identifiers

PMID: 19911060
DOI: 10.1371/journal.pone.0007799
PMCID: PMC2772980

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint.PMID 19911060Read ↗

Paradox of schizophrenia genetics: is a paradigm shift occurring?Semantic proximity Read ↗

Genetics of the schizophrenias: a model accounting for their persistence and myriad phenotypes.Semantic proximity Read ↗

The evolutionary paradox and the missing heritability of schizophrenia.Semantic proximity Read ↗

Cumulative role of rare and common putative functional genetic variants at NPAS3 in schizophrenia susceptibility.Semantic proximity Read ↗

Resolving the paradox of common, harmful, heritable mental disorders: which evolutionary genetic models work best?Semantic proximity Read ↗

The origin of schizophrenia: genetic thesis, epigenetic antithesis, and resolving synthesis.Semantic proximity Read ↗

The cliff edge model of the evolution of schizophrenia: Mathematical, epidemiological, and genetic evidence.Semantic proximity Read ↗

A resistance gene in disguise for schizophrenia?Semantic proximity Read ↗

Luxenburger's 1939 Essay on "Schizophrenia and its Hereditary Circle".Semantic proximity Read ↗

How many genes are involved in schizophrenia? A simple simulation.Semantic proximity Read ↗

Does god play dice with schizophrenia? A probabilistic model for the understanding of causation in mental illness.Semantic proximity Read ↗

Stability of Thought Disorder Index among high-risk and low-risk adoptees in the Finnish adoptive family study of schizophrenia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.