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Article

The cliff edge model of the evolution of schizophrenia: Mathematical, epidemiological, and genetic evidence.

Neuroscience and biobehavioral reviews - 1 May 2024

Mitteroecker Philipp, Merola Giuseppe Pierpaolo

Abstract excerpt

How has schizophrenia, a condition that significantly reduces an individual's evolutionary fitness, remained common across generations and cultures? Numerous theories about the evolution of schizophrenia have been proposed, most of which are not consistent with modern epidemiological and genetic evidence. Here, we briefly review this evidence and explore the cliff edge model of schizophrenia. It suggests that...

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PMID: 38522813
DOI: 10.1016/j.neubiorev.2024.105636

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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