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Article

Resolving the paradox of common, harmful, heritable mental disorders: which evolutionary genetic models work best?

The Behavioral and brain sciences - 1 Aug 2006

Keller Matthew C, Miller Geoffrey

Abstract excerpt

Given that natural selection is so powerful at optimizing complex adaptations, why does it seem unable to eliminate genes (susceptibility alleles) that predispose to common, harmful, heritable mental disorders, such as schizophrenia or bipolar disorder? We assess three leading explanations for this apparent paradox from evolutionary genetic theory: (1) ancestral neutrality (susceptibility alleles were not harmful...

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Identifiers

PMID: 17094843
DOI: 10.1017/S0140525X06009095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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