Accelerated clearance of Plasmodium-infected erythrocytes in sickle cell trait and annexin-A7 deficiency.

doi:10.1159/000257529

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Article

Accelerated clearance of Plasmodium-infected erythrocytes in sickle cell trait and annexin-A7 deficiency.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2009

Lang Philipp A, Kasinathan Ravi S, Brand Verena B, Duranton Christophe, Lang Camelia, Koka Saisudha, Shumilina Ekaterina, Kempe Daniela S, Tanneur Valerie, Akel Ahmad, Lang Karl S, Foller Michael, Kun Jurgen F J, Kremsner Peter G, Wesselborg Sebastian, Laufer Stefan, Clemen Christoph S, Herr Claudia, Noegel Angelika A, Wieder Thomas, Gulbins Erich, Lang Florian, Huber Stephan M

Abstract excerpt

The course of malaria does not only depend on the virulence of the parasite Plasmodium but also on properties of host erythrocytes. Here, we show that infection of erythrocytes from human sickle cell trait (HbA/S) carriers with ring stages of P. falciparum led to significantly enhanced PGE(2) formation, Ca(2+) permeability, annexin-A7 degradation, phosphatidylserine (PS) exposure at the cell surface, and...

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PMID: 19910682
DOI: 10.1159/000257529

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