Article
Genetic analysis of laminin A reveals diverse functions during morphogenesis in Drosophila.
Development (Cambridge, England) - 1 Jun 1993
Henchcliffe C, García-Alonso L, Tang J, Goodman C S
Abstract excerpt
In order to dissect the functions of laminin A in vivo, we have undertaken a molecular and genetic characterization of the laminin A subunit (lamA) gene in Drosophila. Sequence analysis predicts a multidomain structure similar to mammalian homologs. We generated a series of complete and partial loss-of-function mutant alleles of the lamA gene; complete loss-of-function mutations lead to late embryonic lethality....
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