Article

Repeated disuse atrophy imprints a molecular memory in skeletal muscle: transcriptional resilience in young adults and susceptibility in aged muscle

2025-10-16

Abstract excerpt

Disuse-induced muscle atrophy is common after illness, injury, or falls and becomes increasingly frequent with ageing. Whether skeletal muscle retains a “memory” of repeated disuse remains unknown. We investigated repeated lower-limb immobilization in young adults and a refined aged rat model, integrating physiological, multi-omic, immunohistochemical, biochemical, and primary human muscle stem cell (MuSC) analyse...

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Literature Corpus work: 11c82b54-2ea4-52b0-8f60-8ebb3ab1f0d1
DOI: 10.1101/2025.10.16.681134

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