Article
Calcium/Calmodulin-dependent protein kinase II and its endogenous inhibitor α in medullary thyroid cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2014
Russo Eleonora, Salzano Marcella, De Falco Valentina, Mian Caterina, Barollo Susi, Secondo Agnese, Bifulco Maurizio, Vitale Mario
Abstract excerpt
PURPOSE: Calcium/calmodulin-dependent kinase II (CaMKII) is involved in the regulation of cell proliferation. Its endogenous inhibitor (hCaKIINα) is expressed in some cell types. We determined the role of CaMKII in RET-stimulated proliferation and hCaMKIINα in medullary thyroid carcinoma (MTC). EXPERIMENTAL DESIGN: We analyzed the role of RET mutants on CaMKII activation in NIH3T3 and in MTC cell lines, and...
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