Article
Genetic variability in the severity and outcome of community-acquired pneumonia.
Respiratory medicine - 1 Mar 2010
Solé-Violán Jordi, de Castro Felipe v, García-Laorden M Isabel, Blanquer José, Aspa Javier, Borderías Luis, Briones M Luisa, Rajas Olga, Carrondo Ignacio Martín-Loeches, Marcos-Ramos José Alberto, Ferrer Agüero José María, Garcia-Saavedra Ayoze, Fiuza M Dolores, Caballero-Hidalgo Araceli, Rodriguez-Gallego Carlos
Abstract excerpt
BACKGROUND: Several studies have investigated single nucleotide polymorphisms (SNP) in candidate genes associated with susceptibility, severity or outcome in patients with community-acquired pneumonia (CAP) with conflicting results. METHODS: Multi-centre, prospective observational study. We studied 1162 white Spanish patients with CAP and 1413 controls. Severe forms of sepsis were recorded in 325 patients....
Topics
- Aged
- Community-Acquired Infections
- Genetic Predisposition to Disease
- Genotype
- Humans
- Interleukin-6
- Lymphotoxin-alpha
- Male
- Middle Aged