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Article

Genes learn from stress: how infantile trauma programs us for depression.

Epigenetics - 1 Apr 2010

Murgatroyd Chris, Wu Yonghe, Bockmühl Yvonne, Spengler Dietmar

Abstract excerpt

Early-life stress induces persistent memory traces on our genes and programs the life-long risk for depression. Epigenetic marking of the arginine vasopressin (AVP) gene by early-life stress in mice underpins sustained expression and increased hypothalamic-pituitary-adrenal axis activity, triggering endocrine and behavioral alterations that are frequent features in depression. This epigenetic memory evolves in...

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Source

Identifiers

PMID: 20339319
DOI: 10.4161/epi.5.3.11375

Genes

AVP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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