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Article

miR-148a inhibits self-renewal of thyroid cancer stem cells via repressing INO80 expression

25 Oct 2016

Abstract excerpt

Anaplastic thyroid carcinoma (ATC) is aggressive and lethal with extrathyroidal invasion, distant metastasis, and resistance to conventional therapies. Cancer stem cells (CSCs) are proposed to be responsible for high recurrence rate in ATC. MicroRNAs (miRNAs) have recently been found as an important class of cellular regulators of ATC carcinogenesis. Identification of CSC-related miRNAs and targets is therefore a...

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PMID: 27779717
DOI: 10.3892/or.2016.5203

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