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Article

The aromatic ring of phenylalanine 334 is essential for oligomerization of Vibrio vulnificus hemolysin.

Journal of bacteriology - 1 Jan 2010

Kashimoto Takashige, Ueno Shunji, Koga Takeshi, Fukudome Shinji, Ehara Hayato, Komai Mayumi, Sugiyama Hiroyuki, Susa Nobuyuki

Abstract excerpt

Vibrio vulnificus hemolysin (VVH) is thought to be a member of the cholesterol-dependent cytolysin (CDC) family of pore-forming toxins. To date, the structure-function relationships of CDCs produced by Gram-negative bacteria remain largely unknown. We show here that the aromatic ring of phenylalanine residue conserved in Vibrionaceae hemolysins is essential for oligomerization of VVH. We generated the VVH...

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Identifiers

PMID: 19897654
DOI: 10.1128/JB.01049-09
PMCID: PMC2805311

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Source receipt: pubmed, retrieved 7 Sept 2026.

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