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Article

Functional mapping of the lectin activity site on the β-prism domain of vibrio cholerae cytolysin: implications for the membrane pore-formation mechanism of the toxin.

The Journal of biological chemistry - 18 Jan 2013

Rai Anand Kumar, Paul Karan, Chattopadhyay Kausik

Abstract excerpt

Vibrio cholerae cytolysin (VCC) is a prominent member in the family of β-barrel pore-forming toxins. It induces lysis of target eukaryotic cells by forming transmembrane oligomeric β-barrel channels. VCC also exhibits prominent lectin-like activity in interacting with β1-galactosyl-terminated glycoconjugates. Apart from the cytolysin domain, VCC harbors two lectin-like domains: the β-Trefoil and the β-Prism...

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PMID: 23209283
DOI: 10.1074/jbc.M112.430181
PMCID: PMC3548476

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