Article
Low 8-oxo-7,8-dihydro-2'-deoxyguanosine levels and influence of genetic background in an Andean population exposed to high levels of arsenic.
Mutation research - 5 Jan 2010
Engström Karin S, Vahter Marie, Lindh Christian, Teichert Friederike, Singh Rajinder, Concha Gabriela, Nermell Barbro, Farmer Peter B, Strömberg Ulf, Broberg Karin
Abstract excerpt
BACKGROUND: Arsenic (As) causes oxidative stress through generation of reactive oxygen species. 8-Oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), a sensitive marker of oxidative DNA damage, has been associated with As exposure in some studies, but not in others, possibly due to population-specific genetic factors. OBJECTIVES: To evaluate the association between As and 8-oxodG in urine in a population with a low...
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