Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Immunomodulatory effect of 5-azacytidine (5-azaC): potential role in the transplantation setting

4 Nov 2009

Abstract excerpt

Cytokine genes are targets of multiple epigenetic mechanisms in T lymphocytes. 5-azacytidine (5-azaC) is a nucleoside-based DNA methyltransferase inhibitor that induces demethylation and gene reactivation. In the current study, we analyzed the effect of 5-azaC in T-cell function and observed that 5-azaC inhibits T-cell proliferation and activation, blocking cell cycle in the G(0) to G(1) phase and decreasing the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Epigenetics and DNA Methylation
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19887673
DOI: 10.1182/blood-2009-03-210393

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immunomodulatory effect of 5-azacytidine (5-azaC): potential role in the transplantation settingPMID 19887673Read ↗

5-azacytidine promotes an inhibitory T-cell phenotype and impairs immune mediated antileukemic activity.Semantic proximity Read ↗

Azacitidine Mitigates Graft-versus-Host Disease via Differential Effects on the Proliferation of T Effectors and Natural Regulatory T Cells In VivoSemantic proximity Read ↗

Azacitidine augments expansion of regulatory T cells after allogeneic stem cell transplantation in patients with acute myeloid leukemia (AML)Semantic proximity Read ↗

Epigenetic modulation of the immune functionSemantic proximity Read ↗

Immunological effects of hypomethylating agents.Semantic proximity Read ↗

Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancersSemantic proximity Read ↗

The double-edged sword of (re)expression of genes by hypomethylating agents: from viral mimicry to exploitation as priming agents for targeted immune checkpoint modulationSemantic proximity Read ↗

Azacytidine restores T cell function in AML by modulating DNA methylationSemantic proximity Read ↗

Comprehensive comparison between azacytidine and decitabine treatment in an acute myeloid leukemia cell lineSemantic proximity Read ↗

Comprehensive comparison between azacytidine and decitabine treatment in an acute myeloid leukemia cell lineSemantic proximity Read ↗

Differential Effects of Epigenetic Modifiers on the Expansion and Maintenance of Human Cord Blood Stem/Progenitor CellsSemantic proximity Read ↗

Epigenetic therapy of cancer stem and progenitor cells by targeting DNA methylation machineriesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.