Article
Plasma placental RNA allelic ratio permits noninvasive prenatal chromosomal aneuploidy detection.
Nature medicine - 1 Feb 2007
Lo Y M Dennis, Tsui Nancy B Y, Chiu Rossa W K, Lau Tze K, Leung Tse N, Heung Macy M S, Gerovassili Ageliki, Jin Yongjie, Nicolaides Kypros H, Cantor Charles R, Ding Chunming
Abstract excerpt
Current methods for prenatal diagnosis of chromosomal aneuploidies involve the invasive sampling of fetal materials using procedures such as amniocentesis or chorionic villus sampling and constitute a finite risk to the fetus. Here, we outline a strategy for fetal chromosome dosage assessment that can be performed noninvasively through analysis of placental expressed mRNA in maternal plasma. We achieved...
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