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Article

Measurement of allelic-expression ratios in trisomy 21 placentas by quencher extension of heterozygous samples identified by partially denaturing HPLC.

Clinical chemistry - 1 Feb 2008

Go Attie T J I, Visser Allerdien, Betsalel Ofir T, van Vugt John M G, Blankenstein Marinus A, Oudejans Cees B M

Abstract excerpt

BACKGROUND: Measuring the allelic ratios of placental transcripts in maternal plasma permits noninvasive prenatal detection of chromosomal aneuploidy. Current methods, however, require highly specialized equipment (MALDI-TOF), limiting the widespread implementation of this powerful RNA single-nuc...

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Source

Identifiers

PMID: 18223136
DOI: 10.1373/clinchem.2007.095539

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18223136-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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