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Chromatinisation of herpesvirus genomes

4 Nov 2009

Abstract excerpt

The double-stranded DNA genomes of herpesviruses exist in at least three alternative global chromatin states characterised by distinct nucleosome content. When encapsidated in virus particles, the viral DNA is devoid of any nucleosomes. In contrast, within latently infected nuclei herpesvirus genomes are believed to form regular nucleosomal structures resembling cellular chromatin. Finally, during productive...

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PMID: 19890944
DOI: 10.1002/rmv.632

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