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Histone Modifications in Papillomavirus Virion Minichromosomes

15 Feb 2021

Abstract excerpt

A relatively unique feature of papillomaviruses is that the viral genome is associated with host histones inside the virion. However, little is known about the nature of the epigenome within papillomavirions or its biological relevance to the infectious viral cycle. Here, we define the epigenetic signature of the H3 and H4 histones from HPV16 virions generated in cell culture and native human papillomavirus type...

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PMID: 33593981
DOI: 10.1128/mbio.03274-20

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