Article
Nocturnal sleep apnea/hypopnea is associated with lower memory performance in APOE epsilon4 carriers.
Neurology - 23 Aug 2005
O'Hara R, Schröder C M, Kraemer H C, Kryla N, Cao C, Miller E, Schatzberg A F, Yesavage J A, Murphy G M
Abstract excerpt
The authors investigated the relationship between obstructive sleep apnea/hypopnea (OSAH) and cognition in 36 older adults, 18 APOE epsilon4 carriers, and 18 non-carriers. Greater numbers of respiratory events negatively impacted memory function in epsilon4 carriers only. This is the first study...
Topics
- Aged
- Apolipoprotein E4
- Apolipoproteins E
- Brain
- Cognition Disorders
- DNA Mutational Analysis
- Disease Progression
- Female
- Genetic Predisposition to Disease
- Genetic Testing
- Genetic Variation
- Heterozygote
- Humans
- Male
- Memory Disorders