Article
Association of an intronic variant of the heme oxygenase-1 gene with hypertension in northern Chinese Han population.
Clinical and experimental hypertension (New York, N.Y. : 1993) - 1 Oct 2009
Yun Li, Xiaoli Liu, Qi Zhao, Laiyuan Wang, Xiangfeng Lu, Chong Shen, Jianfeng Huang, Shufeng Chen, Hongfan Li, Gu Dongfeng
Abstract excerpt
Heme oxygenase was regarded as a regulator of oxidative stress, which was believed to underlie the etiology of hypertension. To assess the effect of its encoded genes (HMOX1 and HMOX2) on hypertension, we designed a case-control study in 503 cases and 490 controls. The results indicated that the rs9607267 of the HMOX1 gene was significantly associated with essential hypertension (EH) and the Hap3(T-C-G) of the...
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