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Article

New understanding of the molecular mechanism of receptor-mediated genomic actions of the vitamin D hormone.

Bone - 1 Aug 1995

Haussler M R, Jurutka P W, Hsieh J C, Thompson P D, Selznick S H, Haussler C A, Whitfield G K

Abstract excerpt

The nuclear vitamin D receptor (VDR) binds the 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]hormone with high affinity and elicits its actions to regulate gene expression in target cells by binding to vitamin D-responsive elements (VDREs). VDREs in positively controlled genes such as osteocalcin, osteopontin, beta 3-integrin, and vitamin D-24-OHase are direct hexanucleotide repeats with a spacer of three nucleotides....

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Source

Identifiers

PMID: 8579895
DOI: 10.1016/8756-3282(95)00205-r

Genes

VDR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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