Article
New understanding of the molecular mechanism of receptor-mediated genomic actions of the vitamin D hormone.
Bone - 1 Aug 1995
Haussler M R, Jurutka P W, Hsieh J C, Thompson P D, Selznick S H, Haussler C A, Whitfield G K
Abstract excerpt
The nuclear vitamin D receptor (VDR) binds the 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]hormone with high affinity and elicits its actions to regulate gene expression in target cells by binding to vitamin D-responsive elements (VDREs). VDREs in positively controlled genes such as osteocalcin, osteop...
Topics
- Animals
- Base Sequence
- Calcitriol
- Chickens
- Cytochrome P-450 Enzyme System
- DNA
- Gene Expression Regulation
- Humans
- Integrins
- Molecular Sequence Data
- Mutation
- Osteocalcin
- Osteopontin
- Rats
- Receptors, Calcitriol
- Receptors, Retinoic Acid
- Retinoid X Receptors
- Sialoglycoproteins