Article
Why genes extending lifespan in model organisms have not been consistently associated with human longevity and what it means to translation research
2 Sept 2014
Abstract excerpt
A recent paper by Deelen et al. (2014) in Human Molecular Genetics reports the largest genome-wide association study of human longevity to date. While impressive, there is a remarkable lack of association of genes known to considerably extend lifespan in rodents with human longevity, both in this latest study and in genetic association studies in general. Here, I discuss several possible explanations, such as...
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