Article
T cell subsets in the thymus of graft-versus-host immunosuppressed mice. Sensitivity of the L3T4+Lyt-2- subset to cortisone.
Transplantation - 1 Jan 1991
Kornbluth M, You-Ten E, Desbarats J, Gamache S, Xenocostas A, Lapp W S
Abstract excerpt
We have investigated the effects of graft-versus-host disease on T cell differentiation in the murine thymus. We previously reported that GVH-induced thymic dysplasia results in a T cell immunodeficiency associated with a lack of IL-2 production. This deficiency in IL-2 production may be the result of a reduction in the number of L3T4+Lyt-2- IL-2-producing cells or of a functional defect in this population. To...
Topics
- Acquired Immunodeficiency Syndrome
- Adrenalectomy
- Animals
- Antigens, Differentiation, T-Lymphocyte
- Antigens, Ly
- Cortisone
- Graft vs Host Disease
- Graft vs Host Reaction
- Immune Tolerance
- Mice