Article
Renal progenitor cells contribute to hyperplastic lesions of podocytopathies and crescentic glomerulonephritis.
Journal of the American Society of Nephrology : JASN - 1 Dec 2009
Smeets Bart, Angelotti Maria Lucia, Rizzo Paola, Dijkman Henry, Lazzeri Elena, Mooren Fieke, Ballerini Lara, Parente Eliana, Sagrinati Costanza, Mazzinghi Benedetta, Ronconi Elisa, Becherucci Francesca, Benigni Ariela, Steenbergen Eric, Lasagni Laura, Remuzzi Giuseppe, Wetzels Jack, Romagnani Paola
Abstract excerpt
Glomerular injury can involve excessive proliferation of glomerular epithelial cells, resulting in crescent formation and obliteration of Bowman's space. The origin of these hyperplastic epithelial cells in different glomerular disorders is controversial. Renal progenitors localized to the inner surface of Bowman's capsule can regenerate podocytes, but whether dysregulated proliferation of these progenitors...
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