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Article

Identification of five novel 14-3-3 isoforms interacting with the GPIb-IX complex in platelets.

Journal of thrombosis and haemostasis : JTH - 1 Sept 2009

Mangin P H, Receveur N, Wurtz V, David T, Gachet C, Lanza F

Abstract excerpt

BACKGROUND: Binding of von Willebrand factor to the platelet glycoprotein (GP)Ib-IX complex initiates a signaling cascade leading to integrin alpha(IIb)beta(3) activation, a key process in hemostasis and thrombosis. Interaction of 14-3-3zeta with the intracytoplasmic domain of GPIb appears to be a major effector of this activation pathway. OBJECTIVE: The aim of our study was to determine whether other members of...

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Source

Identifiers

PMID: 19558434
DOI: 10.1111/j.1538-7836.2009.03530.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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