Article
Role of the transmembrane domain of glycoprotein IX in assembly of the glycoprotein Ib-IX complex.
Journal of thrombosis and haemostasis : JTH - 1 Dec 2007
Luo S-Z, Mo X, López J A, Li R
Abstract excerpt
BACKGROUND: The glycoprotein (GP) Ib-IX complex is critically involved in platelet adhesion to von Willebrand factor and in the initial step of platelet activation. How this complex is assembled is not clear. We previously showed that the transmembrane (TM) domains of the GPIbalpha and GPIbbeta subunits interact and participate in complex assembly. OBJECTIVES AND METHODS: Here, we have investigated the role of...
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