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Article

Rosiglitazone rescues memory impairment in Alzheimer's transgenic mice: mechanisms involving a reduced amyloid and tau pathology.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jun 2010

Escribano Luis, Simón Ana-María, Gimeno Esther, Cuadrado-Tejedor Mar, López de Maturana Rakel, García-Osta Ana, Ricobaraza Ana, Pérez-Mediavilla Alberto, Del Río Joaquín, Frechilla Diana

Abstract excerpt

Clinical studies suggest that agonists at peroxisome proliferator-activated receptor gamma (PPARgamma) may exert beneficial effects in patients with mild-to-moderate Alzheimer's disease (AD), but the mechanism for the potential therapeutic interest of this class of drugs has not yet been elucidated. Here, in mice overexpressing mutant human amyloid precursor protein, we found that chronic treatment with...

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Identifiers

PMID: 20336061
DOI: 10.1038/npp.2010.32
PMCID: PMC3055461

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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