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Sporadic ALS has compartment-specific aberrant exon splicing and altered cell–matrix adhesion biology

29 Oct 2009

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive weakness from loss of motor neurons. The fundamental pathogenic mechanisms are unknown and recent evidence is implicating a significant role for abnormal exon splicing and RNA processing. Using new comprehensive genomic technologies, we studied exon splicing directly in 12 sporadic ALS and 10 control lumbar...

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PMID: 19864493
DOI: 10.1093/hmg/ddp498

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