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Article

Molecular analysis of different allelic variants of wild-type human p53.

Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Jan 2000

Moreau F, Matlashewski G

Abstract excerpt

The p53 tumour suppressor gene is intensively studied because mutations in this gene are the most common genetic alteration so far identified in human cancer. Considerable emphasis has thus been placed on characterizing the biological differences between mutant and wild-type p53 protein. This has led to the realization that in cultured cells, mutant p53 behaves like an oncogene, whereas wild-type p53 is a tumor...

Topics

3T3 Cells
Alleles
Animals
Antigens, Polyomavirus Transforming
Gene Expression Regulation
Genes, p53
Humans
Mice
Oncogene Proteins, Viral
Papillomavirus E7 Proteins
RNA, Messenger

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombinant Fusion Proteins

Repressor Proteins

Transfection

Tumor Suppressor Protein p53

Source

Identifiers

PMID: 1297328
DOI: 10.1139/o92-145

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1297328-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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