Article
Whole-genome sequencing and social-network analysis of a tuberculosis outbreak.
The New England journal of medicine - 24 Feb 2011
Gardy Jennifer L, Johnston James C, Ho Sui Shannan J, Cook Victoria J, Shah Lena, Brodkin Elizabeth, Rempel Shirley, Moore Richard, Zhao Yongjun, Holt Robert, Varhol Richard, Birol Inanc, Lem Marcus, Sharma Meenu K, Elwood Kevin, Jones Steven J M, Brinkman Fiona S L, Brunham Robert C, Tang Patrick
Abstract excerpt
BACKGROUND: An outbreak of tuberculosis occurred over a 3-year period in a medium-size community in British Columbia, Canada. The results of mycobacterial interspersed repetitive unit-variable-number tandem-repeat (MIRU-VNTR) genotyping suggested the outbreak was clonal. Traditional contact tracing did not identify a source. We used whole-genome sequencing and social-network analysis in an effort to describe the...
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