Functional Characterization of<i>Borrelia spielmanii</i>Outer Surface Proteins That Interact with Distinct Members of the Human Factor H Protein Family and with Plasminogen

Abstract excerpt

Acquisition of complement regulator factor H (CFH) and factor H-like protein 1 (CFHL1) from human serum enables Borrelia spielmanii, one of the etiological agents of Lyme disease, to evade complement-mediated killing by the human host. Up to three distinct complement regulator-acquiring surface proteins (CRASPs) may be expressed by serum-resistant B. spielmanii, each exhibiting an affinity for CFH and/or CFHL1....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Complement system in diseases
• Share to Vector-borne infectious diseases
• Share to Viral Infections and Vectors