Article
Complement resistance of Borrelia burgdorferi correlates with the expression of BbCRASP-1, a novel linear plasmid-encoded surface protein that interacts with human factor H and FHL-1 and is unrelated to Erp proteins.
The Journal of biological chemistry - 23 Jan 2004
Kraiczy Peter, Hellwage Jens, Skerka Christine, Becker Heiko, Kirschfink Michael, Simon Markus M, Brade Volker, Zipfel Peter F, Wallich Reinhard
Abstract excerpt
The etiologic agent of Lyme disease, Borrelia burgdorferi, is capable of circumventing the immune defense of a variety of potential vertebrate hosts. Previous work has shown that interaction of host-derived complement regulators, factor H and factor H-like protein 1 (FHL-1), with up to five complement regulator-acquiring surface proteins (CRASPs) expressed by resistant B. burgdorferi sensu lato isolates conferred...
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