Article
Deciphering the ligand-binding sites in the Borrelia burgdorferi complement regulator-acquiring surface protein 2 required for interactions with the human immune regulators factor H and factor H-like protein 1.
The Journal of biological chemistry - 12 Dec 2008
Siegel Corinna, Schreiber Johanna, Haupt Katrin, Skerka Christine, Brade Volker, Simon Markus M, Stevenson Brian, Wallich Reinhard, Zipfel Peter F, Kraiczy Peter
Abstract excerpt
Borrelia burgdorferi, the etiologic agent of Lyme disease, employs sophisticated means to evade killing by its mammalian hosts. One important immune escape mechanism is the inhibition of complement activation mediated by interactions of the host-derived immune regulators factor H (CFH) and factor H-like protein 1 (CFHL1) with borrelial complement regulator-acquiring surface proteins (BbCRASPs). BbCRASP-2 is a...
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