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Article

The Complement Regulator Factor H Binds to the Surface Protein OspE of Borrelia burgdorferi

1 Mar 2001

Abstract excerpt

Spirochete bacteria of the Borrelia burgdorferi sensu lato complex cause Lyme borreliosis. The three pathogenic subspecies Borrelia garinii, Borrelia afzelii, and Borrelia burgdorferi sensu stricto differ in their disease profiles and susceptibility to complement lysis. We investigated whether complement resistance of Borreliae could be due to acquisition of the main soluble inhibitors of the alternative...

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PMID: 11113124
DOI: 10.1074/jbc.m007994200

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Related research

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The Complement Regulator Factor H Binds to the Surface Protein OspE of Borrelia burgdorferiPMID 11113124Read ↗

Complement Inhibitor Factor H Binding to Lyme Disease Spirochetes Is Mediated by Inducible Expression of Multiple Plasmid-Encoded Outer Surface Protein E ParalogsSemantic proximity Read ↗

Lysine-Dependent Multipoint Binding of the Borrelia burgdorferi Virulence Factor Outer Surface Protein E to the C Terminus of Factor HSemantic proximity Read ↗

Immune evasion of <i>Borrelia burgdorferi</i>: mapping of a complement‐inhibitor factor H‐binding site of BbCRASP‐3, a novel member of the Erp protein familySemantic proximity Read ↗

Complement therapeutic Factor H-IgG proteins as pre-exposure prophylaxes against Lyme borreliae infectionsSemantic proximity Read ↗

Contribution of the Infection-Associated Complement Regulator-Acquiring Surface Protein 4 (ErpC) to Complement Resistance of<i>Borrelia burgdorferi</i>Semantic proximity Read ↗

Functional Characterization of<i>Borrelia spielmanii</i>Outer Surface Proteins That Interact with Distinct Members of the Human Factor H Protein Family and with PlasminogenSemantic proximity Read ↗

Demonstration of the Involvement of Outer Surface Protein E Coiled Coil Structural Domains and Higher Order Structural Elements in the Binding of Infection-Induced Antibody and the Complement-Regulatory Protein, Factor HSemantic proximity Read ↗

The OspE-Related Proteins Inhibit Complement Deposition and Enhance Serum Resistance of Borrelia burgdorferi , the Lyme Disease SpirocheteSemantic proximity Read ↗

CspA-Mediated Binding of Human Factor H Inhibits Complement Deposition and Confers Serum Resistance in Borrelia burgdorferiSemantic proximity Read ↗

Complement resistance of Borrelia burgdorferi correlates with the expression of BbCRASP-1, a novel linear plasmid-encoded surface protein that interacts with human factor H and FHL-1 and is unrelated to Erp proteins.Semantic proximity Read ↗

Expression of complement factor H binding immunoevasion proteins in <i>Borrelia garinii </i>isolated from patients with neuroborreliosisSemantic proximity Read ↗

Deciphering the ligand-binding sites in the Borrelia burgdorferi complement regulator-acquiring surface protein 2 required for interactions with the human immune regulators factor H and factor H-like protein 1.Semantic proximity Read ↗

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