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Article

Molecular defect in coagulation factor XFriuli results from a substitution of serine for proline at position 343.

Blood - 15 Jan 1991

James H L, Girolami A, Fair D S

Abstract excerpt

Our previous findings suggested that coagulation factor XFriuli could be functionally defective owing to a point mutation in the portion of the factor X gene coding for the fully activated heavy chain. To verify the existence of this postulated change, we analyzed all eight exons of the normal and Friuli factor X gene. Each exon was amplified from genomic DNA using the polymerase chain reaction and cloned into...

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PMID: 1985698

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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