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Article

Allele frequency estimation from data on relatives.

American journal of human genetics - 1 Jan 1991

Boehnke M

Abstract excerpt

Given genetic marker data on unrelated individuals, maximum-likelihood allele-frequency estimates and their standard errors are easily calculated from sample proportions. When marker phenotypes are observed on relatives, this method cannot be used without either discarding a subset of the data or incorrectly assuming that all individuals are unrelated. Here, I describe a method for allele frequency estimation for...

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PMID: 1985459
PMCID: PMC1682747

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