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Article

Thermodynamic analysis of substrate induced domain closure of 3-phosphoglycerate kinase.

FEBS letters - 19 Nov 2009

Varga Andrea, Szabó Judit, Flachner Beáta, Gugolya Zoltán, Vonderviszt Ferenc, Závodszky Péter, Vas Mária

Abstract excerpt

The energetic changes accompanying domain closure of 3-phosphoglycerate kinase, a typical hinge-bending enzyme, were assessed. Calorimetric titrations of the enzyme with each substrate, both in the absence and presence of the other one, provide information not only about the energetics of substrate binding, but of the associated conformational changes, including domain closure. Our results suggest that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19854185
DOI: 10.1016/j.febslet.2009.10.048

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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