Article
Pathway identification combining metabolic flux and functional genomics analyses: acetate and propionate activation by Corynebacterium glutamicum.
Journal of biotechnology - 10 Mar 2009
Veit Andrea, Rittmann Doris, Georgi Tobias, Youn Jung-Won, Eikmanns Bernhard J, Wendisch Volker F
Abstract excerpt
Corynebacterium glutamicum can utilize acetic acid and propionic acid for growth and amino acid production. Growth on acetate as sole carbon source requires acetate activation by acetate kinase (AK) and phosphotransacetylase (PTA), encoded in the pta-ack operon. Genetic and enzymatic studies showed that these enzymes also catalyze propionate activation and were required for growth on propionate as sole carbon...
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