Human immunodeficiency virus type 1 variants with increased replicative capacity develop during the asymptomatic stage before disease progression.

doi:10.1128/JVI.68.7.4400-4408.1994

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Human immunodeficiency virus type 1 variants with increased replicative capacity develop during the asymptomatic stage before disease progression.

Journal of virology - 1 Jul 1994

Connor R I, Ho D D

Abstract excerpt

We examined the replicative properties of a series of sequential isolates and biological clones of human immunodeficiency virus type 1 (HIV-1) obtained from an individual who progressed from seroconversion to AIDS in approximately 5 years. HIV-1 isolated soon after seroconversion replicated slowly and to low levels in cultures of peripheral blood mononuclear cells; however, subsequent isolates obtained during...

Topics

Acquired Immunodeficiency Syndrome
Base Sequence
CD4-Positive T-Lymphocytes
Cells, Cultured
DNA Primers
Giant Cells
HIV Reverse Transcriptase
HIV Seropositivity
HIV-1
Humans
Kinetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukocytes, Mononuclear

Macrophages

Male

Molecular Sequence Data

Phenotype

RNA-Directed DNA Polymerase

Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 7515972
DOI: 10.1128/JVI.68.7.4400-4408.1994
PMCID: PMC236364

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7515972-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human immunodeficiency virus type 1 variants with increased replicative capacity develop during the asymptomatic stage before disease progression.PMID 7515972Read ↗

Non-syncytium-inducing HIV type 1 isolated from infected individuals replicates in MT-2 cells.Semantic proximity Read ↗

Evolution of syncytium-inducing and non-syncytium-inducing biological virus clones in relation to replication kinetics during the course of human immunodeficiency virus type 1 infection.Semantic proximity Read ↗

Infection with dual-tropic human immunodeficiency virus type 1 variants associated with rapid total T cell decline and disease progression in injection drug users.Semantic proximity Read ↗

Increased replication of non-syncytium-inducing HIV type 1 isolates in monocyte-derived macrophages is linked to advanced disease in infected children.Semantic proximity Read ↗

In vitro replication kinetics of human immunodeficiency virus type 1 (HIV-1) variants in relation to virus load in long-term survivors of HIV-1 infection.Semantic proximity Read ↗

Monocytotropic human immunodeficiency virus type 1 (HIV-1) variants detectable in all stages of HIV-1 infection lack T-cell line tropism and syncytium-inducing ability in primary T-cell culture.Semantic proximity Read ↗

Early- and intermediate-stage variants of simian immunodeficiency virus replicate efficiently in cells lacking CCR5.Semantic proximity Read ↗

A New Type of Nonsuppressible Viremia Produced by HIV-Infected MacrophageSemantic proximity Read ↗

Persistent CCR5 utilization and enhanced macrophage tropism by primary blood human immunodeficiency virus type 1 isolates from advanced stages of disease and comparison to tissue-derived isolates.Semantic proximity Read ↗

In vivo HIV-1 infection of CD45RA(+)CD4(+) T cells is established primarily by syncytium-inducing variants and correlates with the rate of CD4(+) T cell decline.Semantic proximity Read ↗

Macrophage-tropic variants initiate human immunodeficiency virus type 1 infection after sexual, parenteral, and vertical transmission.Semantic proximity Read ↗

Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus populationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.