Article
The imprinted gene neuronatin is regulated by metabolic status and associated with obesity.
Obesity (Silver Spring, Md.) - 1 Jul 2010
Vrang Niels, Meyre David, Froguel Phillippe, Jelsing Jacob, Tang-Christensen Mads, Vatin Vincent, Mikkelsen Jens D, Thirstrup Kenneth, Larsen Leif K, Cullberg Karina B, Fahrenkrug Jan, Jacobson Per, Sjöström Lars, Carlsson Lena M S, Liu Yongjun, Liu Xiaogang, Deng Hong-Wen, Larsen Philip J
Abstract excerpt
Using restriction fragment differential display (RFDD) technology, we have identified the imprinted gene neuronatin (Nnat) as a hypothalamic target under the influence of leptin. Nnat mRNA expression is decreased in several key appetite regulatory hypothalamic nuclei in rodents with impaired leptin signaling and during fasting conditions. Furthermore, peripheral administration of leptin to ob/ob mice normalizes...
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