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Article

Genetic deficiencies of innate immune signalling in human infectious disease.

The Lancet. Infectious diseases - 1 Nov 2009

van de Vosse Esther, van Dissel Jaap T, Ottenhoff Tom H M

Abstract excerpt

The type-1 cytokine (interleukin 12, interleukin 23, interferon gamma, interleukin 17) signalling pathway is triggered during infection by activation of phagocyte-expressed pattern-recognition receptors that recognise specific pathogen-associated molecular patterns. Triggering of this pathway results, among other things, in activation of microbicidal mechanisms in phagocytic cells. Individuals with a deficiency...

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PMID: 19850227
DOI: 10.1016/S1473-3099(09)70255-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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