Article
The genes associated with trans-dominance of the influenza A cold-adapted live virus vaccine.
Virology - 1 Jan 1991
Whitaker-Dowling P, Zvolenski R, Youngner J S
Abstract excerpt
Segment 7 (M) of the cold-adapted live influenza A virus vaccine plays a primary role in the ability of this virus to interfere with the replication of wild-type influenza A viruses. This conclusion is based on several lines of evidence. Single gene reassortant viruses derived by crossing influenza A/Ann Arbor/6/60 (H2N2) cold-adapted donor virus with an epidemic wild-type strain, A/Korea/1/82 (H3N2), were tested...
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