The genes associated with trans-dominance of the influenza A cold-adapted live virus vaccine.

doi:10.1016/0042-6822(91)90011-y

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Article

The genes associated with trans-dominance of the influenza A cold-adapted live virus vaccine.

Virology - 1 Jan 1991

Whitaker-Dowling P, Zvolenski R, Youngner J S

Abstract excerpt

Segment 7 (M) of the cold-adapted live influenza A virus vaccine plays a primary role in the ability of this virus to interfere with the replication of wild-type influenza A viruses. This conclusion is based on several lines of evidence. Single gene reassortant viruses derived by crossing influen...

Topics

Animals
Cells, Cultured
Chick Embryo
Genes, Viral
Influenza A virus
Phenotype
Serial Passage
Temperature
Vaccines, Attenuated
Viral Interference
Viral Proteins
Viral Vaccines
Virus Replication

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