Article
Voxelwise analysis of diffusion tensor imaging and structural MR imaging in patients with the m.3243A>G mutation in mitochondrial DNA.
AJNR. American journal of neuroradiology - 1 Mar 2011
Virtanen S M, Lindroos M M, Majamaa K, Nuutila P, Borra R J, Parkkola R
Abstract excerpt
BACKGROUND AND PURPOSE: The m.3243A>G mutation is the most common pathogenic mutation in mtDNA; tissues with high dependence on aerobic energy metabolism, such as the brain, heart, and skeletal muscle, are most affected by the ensuing mitochondrial dysfunction. We hypothesized that the m.3243A>G mutation manifests as disturbances in white matter microstructural integrity and volumetric changes in the brain....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.