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Article

Genomic mechanisms of transformation from chronic obstructive pulmonary disease to lung cancer.

Seminars in cancer biology - 1 Feb 2017

Wang Diane C, Shi Lin, Zhu Zhenhua, Gao Danyan, Zhang Yong

Abstract excerpt

Genetic variations in COPD and lung cancer may be one of the molecular mechanisms responsible for COPD-lung cancer transformation. The present review highlights main genetic variations co-existed in COPD and lung cancer and integrates the varied genes into four molecular mechanisms, e.g. activated cell proliferation pathway, tumor suppressor and DNA repair gene dysfunction, chronic inflammatory microenvironment,...

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Identifiers

PMID: 27840275
DOI: 10.1016/j.semcancer.2016.11.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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