Article
CcpA and LacD.1 affect temporal regulation of Streptococcus pyogenes virulence genes.
Infection and immunity - 1 Jan 2010
Kietzman Colin C, Caparon Michael G
Abstract excerpt
Production of H(2)O(2) follows a growth phase-dependent pattern that mimics that of many virulence factors of Streptococcus pyogenes. To gain greater insight into mechanisms coupling virulence factor expression to growth phase, we investigated the molecular basis for H(2)O(2) generation and its regulation. Deletion of the gene encoding lactate oxidase (lctO) or culture in the presence of glucose eliminated...
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